How to slow down aging! A conversation with David Sinclair PhD

This was a fun one! We disagree on a few things but that’s what’s so cool about science! Spolier alert: Ketones turn on longevity genes, as does exercise, heat/cold – Live a RADICAL life, no need for plant molecules! Time stamps: 9:35 Start of podcast. 10:53 Does when you eat matter more than what you eat? 12:48 Time restricted feeding and longevity. 17:04 What causes us to age? 20:05 What cellular information is being lost? 26:35 What Causes DNA break? 28:47 DNA breaks as clastogenesis. 29:32 Food and DNA breaks 31:28 PARP enzymes. 34:57 NAD 40:15 NAMPT 42:35 Nicotinamide and sirtuins. 44:25 Methylation and methyl groups. 45:44 Sirtuins. 48:11 Heat/cold and sirtuins/NAMPT 52:54 What do sirtuins do with ADP ribose. 56:15 Role of active sirtuins. 58:25 Other longevity genes. 1:04:30 Importance of mitochondrial NAD levels. 1:05:50 Ketosis and NAD. 1:11:20 Resveratrol. 1:14:45 Xenohormesis and plant molecules- my view vs David’s 1:19:55 Resveratrol trials, concerns about resveratrol. 1:26:05 mTOR 1:31:37 David’s plant based diet- and why it could be better 1:38:10 Meat consumption and the environment 1:45:35 Where to find David’s stuff. 1:47:20 The most radical thing David has done recently.

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