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NAD or Nicotinamide Adenine Dinucleotide to give it its full name is found in virtually all our living cells, NAD+ is essential for sustaining life. NAD levels decline drastically with age, creating an energy deficit that decreases the body’s ability to retain youthful functions.
NAD is biologically unstable, which makes it unsuitable for oral supplementation. Fortunately, it is easy to restore your cellular NAD levels using NMN (Nicotinamide Mononucleotide) or NR (Nicotinamide Riboside), which converts to NAD when it is in the cell.
To give you an idea how NAD+ declines with age; biological studies have shown that by age 50 a typical person may have only half the NAD+ they did in youth, by age 80, NAD+ (Nicotinamide Adenine Dinucleotide) levels drop to between 1% to 10% of those expressed in youth. A fascinating aspect of NAD+ is its dual role in protecting against factors that age us.
This includes mitigating chemical stress, inflammation, DNA damage, and failing mitochondria, all conditions associated with aging. In other words, while a decline in NAD+ levels may negatively influence lifespan and Healthspan (health-span), so restoring NAD+ is increasingly being viewed as a scientific cutting-edge tool to promote longevity and a way to combat the diseases of aging too.
A rigorous scientific review of NAD+ reveals that its longevity benefits arise from eight different, but interrelated, functions. In 2013 a scientific study; 2-year old mice were tested for muscle wastage, insulin resistance and inflammation, all are, on humans used as indicators of the aging process, they were then given NMN (Nicotinamide Mononucleotide) for 1 week. In all cases, after only 1 week the 2-year old mice were reflecting the expected findings of 6-month old mice in the areas of muscle wastage, insulin resistance and inflammation.
In human terms that would be comparable to a 75-year old having the results you would expect from a 25-year old. In a later methodical study, in 2018, again on mice, Dr. David Sinclair’s team at the Harvard Medical School found that the aging of blood vessels had been reversed.
The science showed that mice that were given NMN (Nicotinamide Mononucleotide) had restored blood vessel growth and had increased muscle endurance by up to 80%. NMN is the pre-cursor to NAD+ (Nicotinamide Adenine Dinucleotide), so what you may say?
NAD+ is used to power out metabolism, at the simplest level, it turns our food into energy. By increasing NAD through NMN or NR (Nicotinamide Riboside) we can kick start those genes again and get them to slow down the aging process; maybe even reverse it. #antiaging#DavidSinclair#Quercetin
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