14 Tips on Preparing for COVID-19 from David Sinclair
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10% Discount Code – MYNMN He opens his newsletter by saying: I feel I have an obligation as a scientist to cut through the politics and shallow reporting. In this time of uncertainty, it is more important than ever to base our views and decisions on facts, and to tell the truth, even if it is hard to hear.
So, what made me really sit up and take note of #NMN Nicotinamide Mononucleotide? I watched a Joe Rogan interview with Dr. David Sinclair where he explained the findings from his 2013 paper and the effects of NMN boosting NAD+ with mice.
In 2013 a study; 2-year old mice were tested for muscle wastage, insulin resistance and inflammation; in humans all are used as indicators of the aging process, they were then given NMN for 1 week. In all cases, after only 1 week the 2-year old mice were reflecting the expected findings of 6-month old mice in the areas of muscle wastage, insulin resistance and inflammation.
In 2018 Dr. David Sinclair’s team at the Harvard Medical School found that the aging of blood vessels had been reversed. The study showed that mice that were given NMN had restored blood vessel growth and had increased muscle endurance by up to 80%.
NMN is the pre-cursor to NAD+, so what you may say? Well NAD+ is used to power out metabolism; simply it turns our food into energy. NAD+ is also responsible for controlling the genes that power the aging process, as we get older our NAD levels drop so the aging genes are allowed to continue unchecked; ergo we get older, the lower the levels the faster we age.
Dr. David Sinclair says that research has shown that by the time we are 50 we have HALF the levels we did when were 20! By increasing NAD through NMN we can kick-start those genes again and get them to slow down the aging process.
To give you an idea how NAD+ declines with age; by age 50 a typical person may have only half the NAD+ they did in youth, by age 80, NAD+ levels drop to between 1% to 10% of those expressed in youth.
A fascinating aspect of NAD+ is its dual role in protecting against factors that age us. This includes mitigating chemical stress, inflammation, DNA damage, and failing mitochondria, all conditions associated with aging. In other words, while a decline in NAD+ levels may negatively influence lifespan, so restoring NAD+ is increasingly being viewed as a cutting-edge tool to promote longevity and a way to combat the diseases of aging too.
A rigorous scientific review of NAD+ reveals that its longevity benefits arise from eight different, but interrelated, functions. Restore Cellular Energy with NAD+
• NAD+ is required for proper cellular energy utilization
• NAD+ levels decline drastically with age, creating an energy deficit that decreases the body’s ability to retain youthful functions
• NAD+ is unstable and cannot be used as a supplement, but NMN a precursor to NAD+ is capable of restoring cellular NAD+ levels
• Studies show that NAD supplementation can slow cellular aging and improve many of the metabolic defects common to the aging process, including obesity, diabetes, cardiovascular disease, and neurodegenerative conditions NAD+ May Contribute to Longer Telomeres
• Telomeres are stretches of repetitive DNA strands that cap the ends of chromosomes. Like the burning of a fuse, telomeres at the ends of our chromosomes steadily shorten every time a cell replicates itself. Once telomeres reach a critically short length, cell renewal virtually stops, leading to accelerated aging or death of the cell.
• Telomere shortening is both a marker of cellular aging and a predictor of shortened lifespan
• NAD+ is required for functioning of the sirtuin proteins that contribute to longevity and specifically to maintaining the length of critical telomeres.
• Certain other nutrients, such as resveratrol, may activate sirtuins and contribute to extending lifespan, but emerging evidence suggests sirtuins function best with an ample supply of NAD+.
• Taking NMN as a supplement is not the magic bullet for longevity. To date, exercise and weight loss have been reliably shown to be effective at telomere lengthening. #antiaging#NAD+ #davidsinclair Acknowledgments: Video: Pexels, Oscar Due Wang Audio: Mrs. Zazzara by Loxbeats https://soundcloud.com/loxbeats Creative Commons — Attribution 3.0 Unported — CC BY 3.0 http://creativecommons.org/licenses/b… Music promoted by Audio Library https://youtu.be/Ct2MXTilkdk